Synthesis and catalytic applications of aziridine-containing scaffolds.

  • 372 Pages
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  • English
Advisor: Andrei
About the Edition

The third project, described in Chapter 3, explored the dimerization of N-H aziridines using Lewis acid catalysts. It was found that in the presence of Yb(OTf)3 and acetoacetates, polymerization was suppressed, and a broad range of 3-[trans-2-(7-aza-bicyclo[4.1.0]hept-7-yl)-cyclohexylamino]-2-butenoates were formed in excellent yields and complete Z selectivity via ring-opening of 7-azabicyclo[4.1.0]heptane.The focus of this thesis is (a) the synthesis and applications of aziridine-derived P,N ligands and (b) the formation of carbon-nitrogen bonds involving aziridines catalyzed by transition metal complexes or Lewis acids. Three projects were examined; the first project, detailed in Chapter 1, involved the ring-opening of aziridines with dialkyl and diarylphosphines as nucleophiles, yielding P,N ligands with a cyclohexane backbone. These ligands were applied to catalytic reactions such as Suzuki coupling and allylic alkylation, exhibiting high reactivity and selectivity.The second project, described in Chapter 2, dealt with the metal-catalyzed coupling of N-H aziridines with aryl and alkenyl bromides as well as aryl and alkenyl boronic acids to form N-aryl and N-alkenyl aziridines in high yields and excellent selectivity. Through the use of such catalytic procedures, a wide variety of new N-alkenyl aziridines were synthesized, which were further transformed through thermal rearrangements.

ContributionsUniversity of Toronto. Dept. of Chemistry.
The Physical Object
Pagination372 leaves.
ID Numbers
Open LibraryOL19475429M
ISBN 100494027088

Details Synthesis and catalytic applications of aziridine-containing scaffolds. PDF

As carbon nanomaterials are used for a variety of applications due to their versatile properties and characteristics, this book discusses recent advances in synthesis methods, characterization, and applications of 0D -3D dimensional carbon nanomaterials.

It is an essential resource for readers focusing on carbon nanomaterials research. Development of Sulfonic-Acid-Functionalized Mesoporous Materials: Synthesis and Catalytic Applications. Chemistry - A European Journal25 (7), DOI: /chem Chang-Sik Ha, Sung Soo Park.

General Synthesis and Physico-chemical Properties of Mesoporous by: INTRODUCTION. Sulfur containing compounds often show different biological activities and serve important functions in applications in the pharmaceutical industry [].Variety of sulfur containing scaffolds widely exists in natural products and drugs (Fig.

1).For instance, epidithiodiketopiperazine (ETP), characterized by sulfur atoms and a diketopiperazine Cited by:   Consequently, several insightful reviews and books that discuss the history and development of mechanochemistry and its application in these areas have been publis26,27,28,29; further in.

9 AZIRIDINES: RETHINKING THEIR APPLICATION AND MANIPULATION IN SYNTHESIS Christopher R. Butler Septem INTRODUCTION Aziridines (1) have been synthetic targets as well as useful building blocks in synthesis since Gabriel’s discovery of the smallest nitrogen containing heterocycle.1,2 Attracted by the increased strain and unique.

select article Pincer complexes, leading characters in C–H bond activation processes. Synthesis and catalytic applications. Synthetic Applications of N-H Aziridine Containing Compounds Shannon Marie Decker Master of Science Table Results of the catalytic experiment between phenyl aziridine aldehyde and Scheme The first step towards the synthesis of an N-vinyl aziridine containing.

Title:Catalytic Asymmetric Biginelli Reaction for the Enantioselective Synthesis of 3,4- Dihydropyrimidinones (DHPMs) VOLUME: 18 ISSUE: 6 Author(s):Jie-Ping Wan, Yunfang Lin and Yunyun Liu Affiliation:College of Chemistry and Chemical Engineering, Jiangxi Normal University, NanchangChina.

Keywords:Asymmetric, Biginelli reaction, catalytic, DHPMs. Clay S. Bennett is an associate professor in the Department of Chemistry at Tufts University, Medford, USA.

Download Synthesis and catalytic applications of aziridine-containing scaffolds. FB2

He received his B.A. in chemistry from Connecticut College (New London, USA) inwhere he carried out undergraduate research in bioorganic chemistry with Prof.

Bruce Branchini. Applications of Nanomaterials: Advances and Key Technologies discusses the latest advancements in the synthesis of various types of nanomaterials. The book's main objective is to provide a comprehensive review regarding the latest advances in synthesis protocols that includes up-to-date data records on the synthesis of all kinds of inorganic.

Synthesis, Technology and Applications of Carbon Nanomaterials explores the chemical properties of different classes of carbon nanomaterials and their major applications. As carbon nanomaterials are used for a variety of applications due to their versatile properties and characteristics, this book discusses recent advances in synthesis methods, characterization, and applications.

Surface modification of magnetic nanoparticles with chiral scaffolds for asymmetric catalytic applications is an elegant way of providing a special pseudo homogenous phase, which could be separated using an external magnet. In this review, we summarize the use of magnetic nanoparticles as a heterogeneous catalyst support in asymmetric synthesis.

Phosphoric acids with planar chiral paracyclophane scaffolds have been prepared in optically pure form starting from 1,8-dibromobiphenylene, by means of a chiral phosphorodiamidate as the phosphorylating agent.

Structural characterization and configurational assignment have been performed by X-ray diffraction studies. The acids promote the organocatalytic enantioselective. Synthesis of atomic nanoclusters (NCs) using proteins as a scaffold has attracted great attention.

Usually, the synthetic conditions for the synthesis of NCs stabilized with proteins require extreme pH values or temperature. These harsh reaction conditions cause the denaturation of the proteins and end up in the loss of their biological functions. Until now, there. About this book Introduction Chapters guide the readers through exploiting a number of protein scaffolds including virus nanoparticles, elastin and collagen peptides and proteins, and other protein templates for either building materials or presentation of ligands.

This Account documents our progress on the rational design and strategic application of asymmetric catalytic cascade reactions in constructing diverse scaffolds and synthesizing complex chiral research is aimed at developing robust cascade reactions for the systematic synthesis of a range of interesting molecules that contain.

(). Synthesis of a series of novel dihydro-[1,2,4]triazolo [1,5-a]pyrimidine scaffolds: Dual solvent-catalyst activity of a low viscous and acid-functionalized ionic liquid.

Synthetic Communications: Vol.

Description Synthesis and catalytic applications of aziridine-containing scaffolds. FB2

50, No. 11, pp. Practical applications of these different gold- and gallium-based catalytic systems for the synthesis of cyclic compounds are presented. 1 Introduction 2 Silver-Free Two-Component Approaches in.

It is currently used as templates and precursors for synthesis of various porous carbon/metal oxides for catalytic applications. Multicomponent TMPs were synthesized from layered double hydroxide (LDH) with nanocage structure by a metal–organic framework (MOF) template-engaged strategy [76], as shown in Fig.

This paper summarizes novel catalytic stereoselective strategies that emerged in the last ten years for synthesis of 1,2,3,4-tetrahydroisoquinoline and 3,4-dihydroisoquinoline scaffolds, beyond the traditional Pictet–Spengler and related protocols, as well as their applications in the total synthesis of alkaloid natural products.

Chiral allenes are important structural scaffolds found in many natural products and drugs, and in addition, they also serve as building blocks for many or. Compared with the same-sized solid, porous or hollow silica spheres, these fantastic spherical silica micro/nanomaterials with hierarchical structures exhibit enhanced properties which may enable them to be used in broad and promising applications as ideal scaffolds (carriers) for biological, medical, and catalytic applications.

Axially chiral anilide compounds are an emerging but scarcely investigated class of stereogenic molecules with potential applications as biologically active scaffolds.

Because of the lower rotation barriers, the synthesis of these compounds is a challenging task. Furthermore, the status of the limited structure type of chiral anilide constrains the latent capacity of the C–N axis as a.

The aim of the present paper is to review systematically the advances in the applications of chiral aziridine-containing derivatives as highly efficient catalysts in asymmetric synthesis.

PDF | Catalysis plays a significant role in improving the catalytic processes to enhance efficiency of chemical transformations by reducing wastes. | Find, read and cite all the research you. However, few known methods allow the synthesis of C-trisubstituted aziridines, particularly for the case of N-unprotected systems [10,16–17].

2,5-Diketopiperazines (DKPs) are readily accessible from amino acids and are versatile synthetic scaffolds [18–19]. Catalytic enantioselective synthesis of carbocyclic and heterocyclic spiranes via a While the preparation of racemic 1,3-diketospiranes such as 1–5 is known and relatively straightforward, 5 these scaffolds are significantly more difficult to prepare as single enantiomers.

6 Depending upon the and application to the synthesis of 1,3. The catalytic and sensing capabilities of cerium nanostructures are highly dependent on their morphologies and can be improved significantly by modifying the sizes and shapes of the nanostructures to develop sensing scaffolds with improved sensing performance.

These nanostructures provide a basis for applications in many fields. The utility of a 'double catalytic enantioselective reaction' is demonstrated by the rapid protecting group-free synthesis of the diterpenoid (−)-cyanthiwigin F, a.

Irishi N N Namboothiri received his MSc from Mangalore University and PhD from Indian Institute of Science, Bangalore. He carried out postdoctoral research at Bar-Ilan University, Israel, University of North Texas and Columbia University.

After a brief stint as Senior Research Scientist at Sabinsa Corporation, New Jersey, he joined the Department of Chemistry, IIT Bombay. Rhodacyclopentanones, an “sp3-rich” class of metallacycle, underpin an emerging range of catalytic methodologies for the direct generation of complex scaffolds.

This review highlights strategies for accessing rhodacyclopentanones (and related species) by C–C bond activation of cyclobutanones or cyclopropanes.Mesoporous titania (mp-TiO2) has drawn tremendous attention for a diverse set of applications due to its high surface area, interfacial structure, and tunable combination of pore size, pore orientation, wall thickness, and pore connectivity.

Its pore structure facilitates rapid diffusion of reactants and charge carriers to the photocatalytically active interface of TiO2.

However. Despite the inherent benefits of multiple catalytic enantioselective reactions, their application to natural product total synthesis remains largely underutilized 2. Here we report the use of a double stereoablative 7 enantioselective alkylation reaction in a concise synthesis of the marine diterpenoid (–)-cyanthiwigin F (ref.